Donnerstag, 30. Juni 2011

Pharmaceutical Marketing Excellence and Sales Force Effectiveness in Europe

Arguably there has never been a more important time for the pharmaceutical industry to review its sales and pharma marketing practices, as the sector faces the patent cliff and more generics are set to enter the market.

For companies which get it right, the benefits of a strong marketing strategy speak for themselves, not just in terms of winning contracts and forging industry partnerships, but also in public perceptions.

Pharma marketing in the digital age


The internet and social media is the big story in the marketing industry at the moment, but with the heavy regulation surrounding the pharmaceutical sector it would be understandable if companies thought it held little promise for them.

Eager to demonstrate this is not the case is Karen Winterhalter, former EMEA managing director of healthcare at Burson Marsteller, who has been appointed by the British government to educate UK pharmaceutical companies on how they can take advantage of digital innovations in marketing and communication.

"In the highly regulated pharmaceutical environment that has traditionally been closed, controlled and selective in its communication, the use of social media may seem an impossibility.

"While many pharma companies have embraced digital comms in the sales environment, few have taken advantage of social media and the opportunities they offer to brands, corporate reputation and internal comms," Winterhalter said.

She added it is imperative pharmaceutical companies step away from the "traditional tell-sell" approach, toward "an open, random and support" methodology.

Using new technology in the field

New technology is also being development to provide a tool for sales agents out in the field to boost customer relationship management (CRM).


January of this year saw Veeva systems release its iRep app, which it described as "the pharmaceutical industry’s first complete CRM and closed loop marketing (CLM) solution built exclusively for the iPad."

The company claimed iPads are increasing being used by pharmaceutical reps out in the field and over the next few months five major US and Europe-based firms are to hand out the tablets with iRep installed to their agents.

Matt Wallach, chief strategy officer at Veeva Systems, said: "Reps are under pressure to represent more products against more competition while physicians give them less face time to do so. iRep allows them to be more efficient, more effective, and more connected.

Cegedim Relationship Management also announced recently it has integrated its Roambianalytics tool for the life sciences industry with mobile technology to provide agents with up-do-date information on CRM or other business information on their iPhone or iPad.

It claims the system will help companies which have limited time with stakeholders to access the most important information in both a timely and effective manner, which in turn will help them form better relationships.

The use of new technology and digital marketing is still a relatively new frontier for the pharmaceutical industry and one which will need to be navigated carefully due to the strict regulations governing the sector.

However, it's clear from the steps being taken by developers, and indeed in some cases governments, that it is one which is expected to grow in importance within the coming years.

Interested in learning more about Pharmaceutical Marketing Excellence and Sales Force Effectiveness? Read more here.

Montag, 27. Juni 2011

Google Shuts Down Medical Records And Health Data Platform


Google is shutting down Google Health, which enables you to store and manage all your health information in one place on the Web. Google says the platform simply wasn’t having the ‘broad impact’ necessary to sustain the product.

From Google’s blog post: There has been adoption among certain groups of users like tech-savvy patients and their caregivers, and more recently fitness and wellness enthusiasts. But we haven’t found a way to translate that limited usage into widespread adoption in the daily health routines of millions of people. That’s why we’ve made the difficult decision to discontinue the Google Health service. 

Google says that it will continue to operate Google Health until January 1, 2012, will allow people to export their health data for an additional year beyond that. Any data that remains in Google Health after that point (January 2013) will be permanently deleted.

Google Health launched in 2008 as a central repository for all of your health information, including prescriptions, medical history, medical records, and more.

One of the key contributors to the overall success of Google Health were partnerships with insurance companies, hospitals and other medical institutions to make data more available to consumers. As last year, Google Health still needed to sign up hundreds of insurers in the U.S. Google announced some key deals (i.e. a partnership with CVS to import prescription data into the platform), but couldn’t gain traction elsewhere.
Google also started transitioning Health into an overall wellness platform, allowing users integrate data from FitBit and CardioTrainer, but clearly this didn’t get enough traction amongst users.

Microsoft’s competing product HealthVault looks to be still alive and kicking.
get widgetminimize
Google Health image
Company: Google
Website: google.com/health
Launch Date: May 19, 2008
Google Health takes users’ medical records and brings them online. Users make personal profiles and add their medical info such as conditions, medications, allergies, procedures, test results, and immunizations. Additionally users can import… Learn More

Freitag, 24. Juni 2011

4th International Symposium Cool Chain - Keeping the pharmaceutical supply chain cool

(PresseBox) Berlin, 23.06.2011, Temperature controlled transportation is still one of the most challenging issues within the pharmaceutical supply chain. From 29 - 31 August 2011, pharmaceutical professionals will come together at the 4th International Symposium Cool Chain in Berlin, Germany, to discuss current issues and developments in the field.

The conference will focus on the following topics:

• Improving selection and validation of transport partners through supplier assessment processes
• Establishing effective controlling and monitoring of transportation from production to the final consumer by using RFID and TTI labels
• Identifying and managing risks along the cool chain (weak spot airport and last mile)
• Current and upcoming EU regulations and industry standards
• Technical solutions such as temperature data logger and multiuse thermo container systems

Companies and institutes such as Roche Diagnostics, Bayer Healthcare AG, Topotarget Switzerland SA, World Courier (Deutschland) GmbH, Pharmaceutical Cold Chain Interest Group (PCCIG) und Sanofi-Aventis will present case studies.

During an interactive workshop day on 31 August, delegates can also further their knowledge in the following areas:

• Qualification of refrigerated trucks and rooms
• Managing the whole transportation process to prevent loss and minimize risks
• Mitigating supply chain risks in the cold chain
• Shipping temperature sensitive clinical supplies

Further information, including articles, interviews and the full conference program can be found at www.cool-chain-conference.com/PR

Montag, 20. Juni 2011

Why Twitter Matters Now in Biotech, and Why Executives Can’t Ignore it Anymore

Luke Timmerman over at xconomy.com wrote an article on why Twitter matters for Biotech, Pharma and related industries. Read the full article below.
by Luke Timmerman 6/13/11
Two years ago, I caved in to the pressure and signed up for a Twitter account. I had been resisting for months. Millions of people were flocking to the 140-character microblogging service, but from what I could see then, it looked like a time-wasting fad.

Hardly anybody in the business I write about, biotechnology, was using it. Since no one in my niche was there, who would care to read my writing? Worse, it seemed like a good way to fragment my attention span into a million little pieces by consuming gossip and trivia, diluting the focus needed to produce in-depth biotech news and feature stories on tight deadlines.

Wrong, wrong, wrong. While I do still have some concerns about what real-time connectivity is doing to humanity, which Bill Keller voiced recently in the New York Times, I’ve come around to the idea that Twitter, used wisely, has potential to be a great force for good in biotech. I’ve been careful to follow people that have valuable and relevant information to report and share, while unfollowing everything else. I’ve expanded my professional network around the world by having conversations with readers I never would have met any other way. I’ve gotten story tips. And this is all happening even while I surmise that fewer than 1 percent of all U.S. life sciences professionals are using the service.

Given how biotech usage of Twitter is still so small, I’ve become convinced that as it grows it will help make the industry much better connected, and maybe even more effective at tackling hard problems like new drug development. It’s already getting to the point where biotechies who aren’t paying attention are putting themselves a few steps behind everyone else who uses it.

The latest example of Twitter’s rising prominence in biotech came from the American Society of Clinical Oncology conference. Last week at this huge gathering in Chicago, there were thousands of real-time bursts of information and commentary on the latest in cancer drug R&D. No one person can keep up with all the details from simultaneous presentations around McCormick Place. And if you rely on major media outlets for coverage, you’re really only hearing about the top dozen or so stories that ASCO’s PR machine doles out to hundreds of reporters there who are writing different versions of the same stories.

With Twitter, the information exchange is real-time, continuous, and comes from a much richer variety of sources than that. It can be overwhelming and messy. But because so many people from various rooms at the conference were filing Tweets in real-time, and funneling them into one place by using the signature #ASCO11, I was able to monitor what was happening at ASCO in real-time from 2,000 miles away. And these dispatches came from an amazing array of people with different kinds of expertise. There were doctors on handheld devices tapping away like @DrAnasYounes and @teamoncology. There was the indefatigable cancer consultant @maverickny. There were stock analysts, like @biotechstockrsr. There were top biotech journalists like @matthewherper and @adamfeuerstein. There were a few pharma companies like @roche_com, @novartis, and @genentechnews who have social media people getting the word out about their products, sometimes in a more thoughtful way than the average press release. If you followed the #ASCO11 topic, you ended up getting some noise, but also a lot of signal. For me, it provided a pretty broad and deep appreciation for what was going on at the conference—like how people were talking about cost-effectiveness of cancer drugs much more this year than in years past.

I’ve talked to a handful of biotech executives about this, and I’ve heard all kinds of objections to signing up to this service. Most of it boils down to fear of the unknown, like I felt two years ago. Biotech is a highly regulated business after all, so executives can’t just go around firing off missives on a smartphone about how wonderful their drugs are if they want to stay on the good side of the FDA. Beyond that, everyone’s busy. I don’t know anybody who feels they have extra time to devote to this thing when they don’t see the value.

Bit by bit, there are a few people out there in biotech showing the way. Michael Gilman, @michael_gilman, has become a master Yoda of sorts for biotech executives curious about entering the social media arena. Gilman, who described his Twitter experience in an Xconomy guest post last November, has expanded his professional network and reputation by making concise, witty comments about biotech news of the day, and passing along story links. Bruce Booth of Atlas Venture, @lifesciVC, is another who has quickly made a bigger name for himself by passing along links to sharp blog posts that I think have to be considered a must-read for any biotech executive or investor. One of the few Twitter-savvy executives at a publicly traded biotech company, Richard Pops of Alkermes @popsalks, has found clever ways to speak out on issues that are important to him, and his company, with a highly targeted audience of followers.

Slowly but surely, I’m running into more biotech execs who are dipping their toes in. Carol Gallagher, the CEO of Calistoga Pharmaceuticals when it was sold to Gilead Sciences earlier this year, said she took the first step by signing up for an account, @carol_gallagher, in mid-May. She had been reluctant for the reasons mentioned above—lack of time, lack of understanding the value. But since she attended ASCO, and monitored the news flow from some of the Twitterers listed above, the light bulb flipped on. “It greatly expands the discussion among people talking about biotech news,” Gallagher says.

She has been hesitant to do much Tweeting herself until she gets the hang of it. But Gallagher says she’s become comfortable now that she realizes she can mostly listen to what people are saying about topics she’s interested in. Even before she really actively engages, Gallagher says she’s already finding networks of people she never would have encountered before.

“In this business, you need all the help you can get in building bridges,” she says. “I’m realizing that I might find a new employee, a new investor, a new partner through this. It really is broadening.”

Carol Gallagher

No doubt, Twitter has a long way to go before it will achieve critical mass among thousands of biotech companies and professionals. The content can get spammy in a hurry if you aren’t careful about who you follow. Brian Reid, a life sciences public relations professional with WCG, has been pushing for companies and researchers to develop more advanced social media habits. He’s been encouraging people to embed QR codes in data posters, so that if somebody tweets “great data from Company X’s drug for breast cancer” they can also snap a photo of the QR code, so there’s a way for followers to click on a link to details that support the claim, which otherwise could look like just some ephemeral blast of hot air.

Personally, I’ve found over time that Twitter is what you want to make of it. It’s more than just a place to share links to my Xconomy stories. It’s become an important way I communicate every day with readers. Besides my stories, it’s a place to comment in real-time with some snappy quotes from a conference, to add two cents on a sporting event (Go Mavs!), or let my followers know where I am in case they want to meet in person. (I’m in Boston this week for a big Xconomy event).

I’ve learned I need to carefully discipline myself to avoid spending too much time trying to monitor everything on Twitter, or even half of what was going on at #ASCO11. That would be a waste of time, and a good way to get ADHD. I try to monitor the stream only a handful of times a day, as a sort of break between other tasks. But I can’t imagine going back to 2009 when I didn’t have this channel for sending and receiving biotech news from a whole lot of very smart people. My bet is that a lot more biotechies are going to see the same thing in the year ahead.


Luke Timmerman is the National Biotech Editor of Xconomy, and the Editor of Xconomy Seattle. E-mail him at ltimmerman@xconomy.com or follow him on Twitter at twitter.com/ldtimmerman.

Mittwoch, 15. Juni 2011

Pfizer Asks Patients to Test Themselves

Can patients uphold the rigorous standards of clinical testing, outside of the clinic? Pfizer is betting that they can, at least for a drug that’s already spent a decade on the market.


Last week, Pfizer announced its new Research on Electronic Monitoring of OAB Treatment Experience (REMOTE) project—a clinical trial for already-approved overactive bladder medication Detrol LA that is to be conducted entirely remotely, using cell phones and Internet access to recruit and follow trial participants over the next year or so.

Why a clinical trial for a drug that’s been on the market for more than ten years? Pfizer decided that a safe, approved medication would be an ideal way to test the method of virtual clinical trials without too much worry about testing the drug itself—the remote trial will attempt to replicate past Detrol clinical trial results, thus helping determine the efficacy of the remote process, more so than the efficacy of the medication, explains Craig Lipset (pictured above), Pfizer’s head of clinical trial innovation (and one of this year’s Pharm Exec Emerging Pharma Leaders). “It’s new patients, but were using the same eligibility criteria and looking at the same endpoints in terms of measures of efficacy and safety,” he explains. “That will give us a good opportunity to understand if these patients are different in some way. First, demographically, when we’re finding patients entirely online versus through the more conventional brick and mortar site approach, and second, if the data we gather from these patients differs in some way in terms of the efficacy and safety they report.”


Patient recruitment is under way, and once patients have been selected, they will each receive a package in the mail containing the necessary medication and—of all things—a smartphone. “We are using a mobile app to enable patients to track what we call a bladder diary—a three-day diary to track their urinary frequency. For patients with overactive bladder, they use that diary a lot, so we didn’t want it to live on their computer where it may not always be accessible,” explains Lipset. “We’re looking at roadmaps for tomorrow where we could push an app to a patient’s own smartphone, but in the world of electronic patient-reported outcomes (EPRO), we’re still not there. We’re not fully comfortable and confident with the security. And if patients use their own smartphones for the trial and then download Angry Birds, what’s the impact going to be on the secure diary app? Is it somehow going to interfere?”


Though the process of conducting clinical trials remotely is unprecedented, Lipset insists that Pfizer didn’t come up with anything all that new—only leveraged existing technologies in new ways. “There really wasn’t a need to reinvent things—telemedicine and remote patient monitoring have already addressed many of the issues for us,” says Lipset. “Somebody chided me the other day, saying ‘Congrats, you’ve caught up with technology that’s 20 years old.’ We didn’t create the Internet, we didn’t create today’s e-patient system, and we didn’t create mobile apps or social media—these trends are happening all around us. It’s just important that we understand these trends and try to keep evolving.”

Be that as it may, when Pfizer brought the idea to FDA, it was still uncharted territory, with no existing paperwork or procedures in place. How was such a novel idea received by an organization that’s all about policies and regulations? “In our first meeting with the FDA, the room was packed—both with FDA and Pfizer bringing legions of people in. But it wasn’t really to debate—it was to collaborate and find solutions, and it was a great experience in demonstrating the FDA’s willingness to support innovation.” The only truly unheard of part of the new trial method that the FDA had to tackle, says Lipset, was drug distribution—Pfizer had to acquire a waiver in order to be able to ship drugs directly to patients’ homes. If remote clinical trials take off in a big way, Lipset predicts FDA will then have to institute further policies and standards, to avoid having to issue such a waiver every time.

So while the whole process seems relatively cut and dried—and shockingly simple—it does raise some questions, about safety, accuracy of reporting, and even cost. The biggest ethical concern and possible liability would come in the event of any serious adverse events (SAEs). While this may not be a huge concern with a medication for overactive bladder that’s already on the market, it’s something that’s got to be looked at down the line if remote trials will ever go mainstream. Lipset says that the process here is very much like the cautionary steps that are typically taken in any traditional, site-based trial—if serious side effects or problems occur, patients often report to their primary care physician (PCP) or local emergency room, not to the trial investigators.

“Imagine a trial for other types of drugs, such as a neuropsychiatric agent for a patient who is depressed. If you’re a patient in that trial who is suddenly suffering chest pain, you’re not going to go to your psychiatrist—you’re going to go to the ER or your cardiologist,” explain Lipset. “So even in those cases, where you’re going for acute care for an adverse event is not back to the investigator in your research study.” This is true regardless of whether the study is remote or site-based, he says.

“I think one of the interesting differences for this project is that patients are connected to the trial 24/7, and it gives us the opportunity to respond in real-time if there are safety issues. We feel that this level of continuous, real-time engagement actually exceeds the current standards and baseline for safety monitoring in conventional trials.”

Similarly, remote trials could potentially result in speedier, more accurate data as well, says Lipset. The key here is that patients can report outcomes, behaviors, side effects, and perceived results as they happen (such as checking in to a bladder diary throughout the day), rather than waiting six weeks or so to report back to a typical trial investigator on-site. “Think about the barriers in place for existing large-scale trials. With multiple sites to select and activate, we have to find patients and recruit them in proximity to those sites. This model has simplified many of those time-intensive tests,” explains Lipset. “And in terms of the quality of the data, we’re now more actively engaging the patient as a participant in the research. We believe that an engaged patient is more likely to persist in the study and more likely to self-report higher-quality data—their data is being reported to us as it happens.”

Finally, cost is something that may change down the line, as the remote trial process is perfected and mainstreamed. “For this first go as a pilot program, I think there’s a lot of buildup that’s needed and so we’re not going to see very significant savings. But our expectation is that this model will help mitigate rising costs of clinical trials, in that some of the most significant costs in clinical trials are starting up investigator sites,” says Lipset.

When pressed about whether these potential lower costs could contribute to lower drugs prices for consumers or generally lower healthcare costs down the line, Lipset responds carefully: “I think there are certainly many benefits to lower costs of clinical trials, both in terms of burden on the overall healthcare system but also the ability to—we in pharma have to constantly allocate a limited pool of resources to the development of new medicines. And so when we find better, smarter, faster ways to develop our medicines, it can also mean more resources available to move more of those other drugs through the pipeline.”

For now, Lipset makes no promises, but recognizes that what Pfizer is doing is a first attempt at a process that will require trial and error, as well as input from the rest of the industry. “Our underlying belief right now is that Pfizer doesn’t own this approach,” he says. “This is in the public domain, and the tools are readily available. And if we want to use this method more broadly at Pfizer, we need it to become a widely accepted method. If Pfizer is the only one doing this, it’s always going to come with challenges and questions and it won’t really become a robust method. So we have an interest in socializing this, and sharing what’s worked so far.”

pfizer

Donnerstag, 9. Juni 2011

IQPC regularly interviews influencers in the Pharma industry, listen to our latest Podcasts

IQPC regularly interviews influencers in the Pharma industry, listen to our latest Podcasts. You can listen online or download these files and listen to them "on-the-road". Enjoy:

podcast-symbolHow to avoid mistakes in cold chain transportation
Christoph Frick, Head of Quality Assurance and Pharmaceutical Development at KohlPharma, joins Helen Winsor from Pharma IQ, to discuss how to ensure the safety and integrity of products during cold chain transportation with an external carrier.

podcast-symbol
Temperature controlled distribution: The challenge of the last mile
Henry Ames, Director of Strategic Marketing for Sensitech, and Lauren Kelleher from Pharma IQ, discuss existing strategies for maintaining consistent temperatures throughout the cold chain process, the difficulty in maintaining strict adherence to 2-8 degrees Celsius and some of the specific challenges around last-mile monitoring.

Montag, 6. Juni 2011

Targeting New Markets to Improve Pharma Sales Force Effectiveness

Sales force effectiveness is highly important for companies within the pharmaceutical industry. Current economic conditions, coupled with increased competiveness, mean that pharmaceutical companies must stay ahead in a changing market. Despite this, it has been suggested by some that the effectiveness of the pharma sales force is, in fact, decreasing.

A report on Pharmaceutical Sales Force Effectiveness Metrics, compiled by Dr Andree Bates, cited figures from the IMS that showed the effectiveness of the pharma sales force decreased by 23 per cent just in the years 2004 to 2005.

According to Dr Bates, the performance of the sales force was actually being impeded by the metrics that are being used to measure its success.


"Sales force effectiveness is a difficult concept to measure, but doing so can push pharmaceutical companies past today's hurdles and into increased productivity and sales," Bates stated in the report.

Pharma Sales Force Characteristics

Bates said that in recent years pharmaceutical firms have been recruiting large numbers of pharma sales reps, which they believed would increase productivity. However, the hiring had no correlation to the number of new products that were being placed on the market.

The growing staff numbers have led to increased pressure on the pharma sales force from a marketing department with an increasingly tight budget. In addition to this, Bates said that the pharma sales force is younger and less experienced, the time it takes a competitor product to get to market has decreased and high-volume clients are being increasingly targeted – which is leading to physicians being swamped with calls from reps, meaning calls are shorter and of a lower quality.


On the subject of the market in Western Europe, Bates said: "With too much of a focus on sales force numbers and efficiency - factors that actually detract from sales force effectiveness - many companies lack standard processes through their sales force activities."

A lack of standardisation among the pharma sales force was said to be an increasing problem, as were issues relating to targeting.

Bates explained that reps were working off random lists of physicians and spending too much time with the wrong people. Customer data about the European region was said to be restricted in comparison to the range of data available in the US.

Changing Markets
In March, a report released by the IMS identified what was described as an "unprecedented shift" within the growth of the pharmaceutical industry.

Some 17 markets across the world were identified as being 'pharmerging', which are expected to grow by US $90 billion (£59 billion) between 2009 and 13 and contribute 48 percent of annual market growth in 2013.

Increased access to healthcare across the globe and the "changing mix of generic and innovative products" were said to be some of the drivers behind this shift.

Murray Aitken, senior vice president, Healthcare Insight, IMS, said: "These are all diverse markets with their own unique healthcare funding, delivery and distribution characteristics. But collectively, they offer strong growth prospects fuelled by rising GDPs, expanding access to healthcare, and in many cases, an improving regulatory environment."

China was said to offer the biggest opportunities for growth, thanks to its large gross domestic product, and was classed as a Tier One market. Much of the demand was said to be for domestically manufactured products, however the IMS said some demand for global innovations could be found in cities.

Tier Two markets included Brazil, Russia and India, which are each expected to add $5 to 15 billion in annual pharmaceutical sales by the year 2013.

Following these in the Tier Three category was Venezuela, Poland, Argentina, Turkey, Mexico, Vietnam, South Africa, Thailand, Indonesia, Romania, Egypt, Pakistan and the Ukraine.

These are the markets which will need to be targeted to improve pharma sales force effectiveness.

David Campbell, senior principal, Pharmerging Markets, IMS, said: "Pharmaceutical manufacturers that lead in building out organisational competencies, tailoring portfolios and adapting business models to these new markets will reap the benefits of differentiation and entrenched presence compared to those that wait."



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Pharma Sales Force 2011
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17. - 20. Oktober 2011 im Meliá Hotel in Berlin.

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