PLM in Sanofi: Safer Projects & Accelerated Timelines for Development

In this interview Philippe Lienard, Head of the Early Development Unit at Sanofi explains the approach they have taken in the anticipation method for chemical stability which has resulted in safer projects and accelerated the timeline for development.

Product lifecycle management is a holistic approach to emerging product and process knowledge that spans the stages of a product from conception through to commercialisation, thus improving the manufacturing process and quality of products.

Pharma IQ: Philippe, could you describe what’s happening in the industry currently around the whole latest product lifecycle management strategies and how this can be used to optimise product development processes? 

P Lienard: So to optimise the product development process we are particularly involved in some in-silico approach to assess the properties of the candidate to enter in development, and the benefit of this will be to anticipate any potential issues regarding, for example, chemical stability, solubility, crystalinity, whatever property will be very key for the drug development.
 

Pharma IQ: What strategies do you use at Sanofi to design and create safer products?

P Lienard: So the strategy is to test the compound on several animal models and for this we have to address a formulation for animals. Generally, those formulations are designed to anticipate the clinic formulation and so it allows us to determine the safe dose, the maximum tolerated dose, and it’s a good starting point for the first treatment.

Continue reading the  interview here.

Learn more at our next conference for a  business transformation approach:  
International Conference PLM in Pharmaceutical & Biotechnical Development
http://bit.ly/MriGOv